Altered renal hemodynamic and excretory response to aminoacids when nephron number is diminished

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Nephron number, hypertension, renal disease, and renal failure.

Wendy E. Hoy,* Michael D. Hughson, John F. Bertram, Rebecca Douglas-Denton, and Kerstin Amann *Centre for Chronic Disease, University of Queensland, Brisbane, Australia; University of Mississippi Medical Center, Jackson, Mississippi; Department of Anatomy and Cell Biology, School of Biomedical Sciences, Monash University, Victoria, Australia; and Department of Pathology, University of Erlangen-...

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Altered Renal Hemodynamic and Urinary Prostaglandin Response to Acute Hypoxemia after Inhibition of Prostaglandin Synthesis

Anesthetized dogs were studied to characterize the renal hemodynamic response to acute, transient hypoxemia and to determine the role of renal prostaglandins (PGE and PGF) in that response. Acute hypoxemia of 10 minutes duration (mean arterial Po2 32 ± 9 torr) induced a reversible increase in renal blood flow (RBF) (measured by electromagnetic flow probe) and mean arterial pressure (MAP) with a...

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Altered Renal Hemodynamic and Urinary Prostaglandin Response to Acute Hypoxemia after Inhibition

Anesthetized dogs were studied to characterize the renal hemodynamic response to acute, transient hypoxemia and to determine the role of renal prostaglandins (PGE and PGF) in that response. Acute hypoxemia of 10 minutes duration (mean arterial Po2 32 ± 9 torr) induced a reversible increase in renal blood flow (RBF) (measured by electromagnetic flow probe) and mean arterial pressure (MAP) with a...

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Nephron number and renal risk in hypertension and diabetes.

It has been proposed that "nephron underdosing," i.e., a low number of nephrons at the time of birth, is linked to essential hypertension and a greater propensity to develop progressive loss of renal function after renal injury. This hypothesis was confirmed recently by examining the number of glomeruli in patients with essential hypertension. The mechanisms through which a low number of nephro...

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Renal hemodynamic and excretory responses to intra-arterial infusion of peroxynitrite in anesthetized rats.

Peroxynitrite (ONOO(-)) is formed endogenously by the reaction of nitric oxide (NO) and superoxide (O(2)(-)). To examine the hypothesis that OONO(-) cause renal vasodilation at low concentrations but cause vasoconstriction at higher concentrations, we examined renal responses to intra-arterial infusion of incremental doses of OONO(-) (10, 20, and 40 microg.kg(-1).min(-1); 45 min each) in anesth...

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ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2007

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.21.6.a894